> ## Documentation Index
> Fetch the complete documentation index at: https://docs.biohub.ai/llms.txt
> Use this file to discover all available pages before exploring further.

# ESMFold2

> Fold proteins with DNA, RNA, and ligands, and design binders with ESMFold2.

<Card title="View tutorials on GitHub" icon="github" href="https://github.com/Biohub/esm/tree/main/cookbook/tutorials" horizontal />

<Columns cols={2}>
  <Card title="Folding with ESMFold2" icon="https://mintlify.s3.us-west-1.amazonaws.com/biohub-8940d923/icons/colab.svg" href="https://colab.research.google.com/github/Biohub/esm/blob/main/cookbook/tutorials/esmfold2.ipynb">
    Fold proteins in combination with DNA, RNA, and small-molecule ligands.
  </Card>

  <Card title="Binder design" icon="github" href="https://github.com/Biohub/esm/blob/main/cookbook/tutorials/binder_design.ipynb">
    Design antibodies and minibinders with high hit rates. Implements the protocol featured in our
    paper, which produced binders exhibiting nanomolar affinity, target specificity, and functional
    activity in laboratory assays.
  </Card>
</Columns>